Digital biology: challenges remain

Pediatric MLBL: challenges remain.

In this issue of Blood, Gerrard et al report the outcome and histologic classification of children and adolescents with mediastinal large B-cell lymphoma (MLBL), and highlight the need for new treatment strategies.

Digital Biology

Digital biology

EDitoriaL EDitoriaL Just two years after the creation of Synthia (JCVI-syn1.0), 1,2 synthetic biology welcomes its second citizen; a whole-cell computational model of the uropathogenic bacterium Mycoplasma genitalium. 3 However, unlike JCV1-syn1.0—the first self-replicating species on the planet whose parent is a computer—Karr's creation exists only in digital form. 3 This bacterial avatar repr...

New pain drugs in pipeline, but challenges to usage remain.

O ver the past two decades, pain control has become a front-burner issue among oncologists, but glaring problems in treating pain remain, a new survey shows. Barriers limiting pain control include patients' reluctance to report pain and to take opioids, coupled with physicians' reluctance to prescribe them, as well as increasing regulatory barriers, according to a study in the Nov. 14 online is...

HCV cure for everyone or which challenges remain?

Following the approval of the first HCV direct-acting antiviral (DAA) in 2011, an unforeseen revolution in the treatment of chronic hepatitis C has taken place. In 2015 several all-oral DAA regimens, combining agents from different families (NS5B nucleotide inhibitors, NS5B non-nucleoside inhibitors, NS5A replication complex inhibitors and NS3/4A protease inhibitors) are now commercially availa...